Report: 49ers WR Brandon Aiyuk (shoulder) to miss game vs. Giants

The San Francisco 49ers don’t expect to have wide receiver Brandon Aiyuk available when they host the New York Giants on Thursday night, ESPN reported.

Aiyuk was listed as questionable for the game because of a shoulder injury sustained Sunday on his first reception against the Los Angeles Rams. He went on to make two more catches and finished with 43 yards in a 30-23 road victory.

He has gotten off to a strong start this season, earning NFC Offensive Player of the Week honors for his effort in a 30-7 win at Pittsburgh in Week 1. Aiyuk made eight catches for 129 yards and two touchdowns.

The 49ers on Thursday activated wide receiver Chris Conley as well as cornerbacks Tre Swilling and Shemar Jean-Charles from the team’s practice squad to the active roster, and released cornerback Anthony Brown.

Aiyuk, 25, was a first-round pick (25th overall) in the 2020 NFL Draft out of Arizona State. In his fourth season with the 49ers, he has started 46 of 48 games and has 205 receptions for 2,761 yards and 20 touchdowns. He also has rushed 13 times for 117 yards and two scores.